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1,10-Phenanthroline-5,6-dione and L-tyrosine methyl ester react to form phenanthroline-oxazine (PDT) from which [Cu(PDT) 2 ](ClO 4 ) 2 and [Ag(PDT) 2 ]ClO 4 Á2MeOH are obtained. Binding to calf-thymus DNA by Ag(I) and Cu(II) PDT complexes exceed bis-1,10-phenanthroline analogues and the minor groove binding drugs, pentamidine and netropsin. Furthermore, unlike the artificial metallonuclease, [Cu(phen) 2 ] 2+ , the [Cu(PDT) 2 ] 2+ complex does not cleave DNA in the presence of added reductantdoi:10.1039/c3cc38710k pmid:23407675 fatcat:eiakzy4tfnhfdehq6zroh37rla