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Asymmetric Whole-Cell Bio-Reductions of (R)-Carvone Using Optimized Ene Reductases
2019
Molecules
(2R,5R)-dihydrocarvone is an industrially applied building block that can be synthesized by site-selective and stereo-selective C=C bond bio-reduction of (R)-carvone. Escherichia coli (E. coli) cells overexpressing an ene reductase from Nostoc sp. PCC7120 (NostocER1) in combination with a cosubstrate regeneration system proved to be very effective biocatalysts for this reaction. However, the industrial applicability of biocatalysts is strongly linked to the catalysts' activity. Since the
doi:10.3390/molecules24142550
fatcat:65cyf2n45vedlmiz7yiriqvthi