Ack1 Mediates Cdc42-dependent Cell Migration and Signaling to p130Cas

Katarzyna Modzelewska, Laura P. Newman, Radhika Desai, Patricia J. Keely
2006 Journal of Biological Chemistry  
2 The abbreviations used are: SH, Src homology domain; CRIB, Cdc42/Racinteractive binding; HA, hemagglutinin; SD, substrate domain; EGFP, enhanced green fluorescent protein; GST, glutathione S-transferase; Ack, activated Cdc42-associated kinase; HEK, human embryonic kidney; siRNA, short interfering RNA. RESULTS Cdc42 Induces Cell Migration through p130 Cas -We previously reported that stable expression of constitutively active Cdc42(12V) caused increased migration of T47D breast epithe-
doi:10.1074/jbc.m604342200 pmid:17038317 fatcat:tmqxogxmlfgo3hqaw3jmpsrq5y