Development of Supramolecular Saccharide Sensors Based on Cyclodextrin Complexes and Self-assembling Systems

Yuji Tsuchido, Shoji Fujiwara, Takeshi Hashimoto, Takashi Hayashita
2017 Chemical and pharmaceutical bulletin  
Cyclodextrins (CDs) are water-soluble host compounds having nano-size hydrophobic cavities that enable them to incorporate organic molecules in water. Optically inert CDs can be efficiently combined with various types of chromoionophores and fluoroionophores. In this study, using diverse combinations of phenylboronic acid fluorescent sensors and azoprobes with CDs, the unique saccharide recognition functions of CD, chemically modified CD, and CD gel complexes based on their synergistic function
more » ... are clarified, thereby confirming their use as supramolecular saccharide sensors. To realize novel supramolecular chirality, the twisted structure of two ditopic azoprobes inside the γ-CD chiral cavity is controlled by multi-point recognition of guest ions in water. As different types of supramolecular saccharide sensors, phenylboronic acidbased self-assembling systems are also reviewed.
doi:10.1248/cpb.c16-00963 pmid:28381670 fatcat:tvasds532faa3kkq3dz3ucswei