Chronic Low-grade Inflammation and Haematological, Circulatory, Metabolic, and Hepatic Abnormalities in Childhood Obesity

Reizo Baba, Osaaki Ando, Kyoko Shinohara, Jun Tanaka
2011 Open Journal of Pediatrics  
Little is known as to the associations between childhood obesity and chronic low-grade inflammation, circulatory, hepatic, metabolic and haematological abnormalities. Methods and Results: A total of 1,871 boys and 1,810 girls were measured anthropometric data, white blood cell (WBCC), platelet count, blood pressure, plasma concentrations of aspartate aminotransferase (AST), alanine aminotransferase (ALT), triglyceride (TG), and highdensity (HDL) lipoprotein cholesterol,. The subjects were
more » ... fied into three body mass index categories depending on the international standard definition for child overweight and obesity. WBCC, platelet counts, systolic blood pressure, serum levels of aminotransferases,TG and HDL-cholesterol were related with body composition in both boys and girls. Obese girls had high risks of having abnormal levels of WBCC, platelet count, systolic blood pressure (SBP), ALT, TG, HDL-cholesterol. Obese boys had high risks of having abnormal levels of WBCC, haemobobin concentration, platelet count, SBP, diastolic blood pressure, AST, ALT, TG, and HDL-cholesterol. Conclusions: Childhood obesity is related with chronic inflammation, hypercoagulability, as well as circulatory, metabolic, and hepatic abnormalities.
doi:10.4236/ojped.2011.11002 fatcat:g62xpva775d4fntistca4edv7q