Normal tissue injury may lead to severe late side effects after therapeutic use of irradiation. Radiation myelopathy (RM) is an uncommon complication of therapeutic irradiation whenever the spinal cord is included within the radiation treatment field. Several factors such as radiation dose, fractination, linear energy transfer, chemotherapy, modify its occurrence and severity. Herein, we report a 43-year-old male patient with nasopharyngeal cancer who developed RM after concomitant chemoradiotherapy and discussed the literature.