Antimicrobial and toxic potential of aqueous extracts of Allium sativum, Hibiscus sabdariffa and Zingiber officinale in Wistar rats

Faoziyat A. Sulaiman, Muinat O. Kazeem, Ahmed M. Waheed, Simisade O. Temowo, Idris O. Azeez, Faridat I. Zubair, Temitope A. Adeyemi, Azido Nyang, Oluyomi S. Adeyemi
2014 Journal of Taibah University for Science  
Allium sativum, Hibiscus sabdariffa and Zingiber officinale are medicinal plants with wide use in traditional medicine; however, the increasing use of crude extracts for traditional medicine applications raises safety concerns. We made a preliminary determination of the phytochemical constituents and antimicrobial and safety profiles of aqueous extracts of A. sativum, H. sabdariffa and Z. officinale. The extracts were administered orally to Wistar rats for 30 days: a control group received
more » ... group received distilled water, three groups received the three extract, and a fifth group received a combination of the three extracts. All three extracts, either individually or in combination, had antimicrobial activity, and all extracts influenced the activities of marker enzymes. The evidence lends credence to use of these plants in traditional medicine but also suggests the probable toxic potential of crude plant extracts.
doi:10.1016/j.jtusci.2014.05.004 fatcat:bhehqgdj75c4ngrmi2wuqjm2ze