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umor necrosis factor-alpha (TNF-) is a proinflammatory cytokine with a broad range of pleiotropic effects. 1 The adult human heart expresses both mRNA and receptor proteins for type I and type II TNFreceptors. 2 TNF-is also expressed de novo by cardiac myocytes after certain forms of stress 3 and plays a fundamental role in various pathophysiological conditions, including acute myocarditis, myocardial infarction, sepsisassociated cardiac dysfunction, and advanced congestive heart failure. doi:10.1253/circj.67.347 pmid:12655167 fatcat:bf6xgjaz5fgwzoibnjt4qth7pu