The association of resistin with cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis

Evan D. Muse, David I. Feldman, Michael J. Blaha, Zeina A. Dardari, Roger S. Blumenthal, Matthew J. Budoff, Khurram Nasir, Michael H. Criqui, Mary Cushman, Robyn L. McClelland, Matthew A. Allison
2015 Atherosclerosis  
Objective-To describe the relationship between circulating resistin levels and cardiovascular diseases (CVD) and all-cause death in a multi-ethnic cohort. Methods and Results-We studied 1,913 participants from the Multi-Ethnic Study of Atherosclerosis with measurements of plasma resistin levels. Absolute proportions experiencing new-onset atrial fibrillation (AF), atherosclerotic CVD (myocardial infarction, angina, resuscitated cardiac arrest, stroke), heart failure (HF), and all-cause death
more » ... e calculated for each quartile of resistin. We used adjusted Cox proportional regression modeling resistin as a continuous variable per standard deviation of log-transformed resistin and secondarily as a categorical variable using resistin quartiles. Results were stratified by sex and race/ethnicity. The mean age of the population was 64.5 ± 10 years with half being female and a median resistin concentration of 15.1 ng/mL (11.9-19.1). Mean follow-up time was 7.2 ± 1.8 years. There was a graded increase in the occurrence of all outcomes across increasing quartiles of resistin. Modeled as a continuous variable, after adjustment for anthropomorphic measures, traditional risk factors, markers of
doi:10.1016/j.atherosclerosis.2014.12.044 pmid:25585029 pmcid:PMC4331252 fatcat:klfpl4clsjh7dgzhbfnjrszq5a