Synthesis, Semiempirical, Stereoselectivity and Pharmacological Activity of a New Class of Spiro Pyrrolidine and Isoquinoline Derivatives

A.V. Londhe, B. Gupta, S. Kohli, P. Pardasani, R. T. Pardasani
2006 Zeitschrift für Naturforschung. B, A journal of chemical sciences  
1,3-Dipolar cycloaddition of azomethine ylides derived from acenaphthylene-1,2-dione and 5- methyl-benzo[b]-thiophene-2,3-dione with L-proline, thiazolidine-4-carboxylic acid and 1,2,3,4- tetrahydroisoquinoline-3-carboxylic acid with various electron deficient dipolarophiles leads to the formation of novel spiroheterocycles having two or more chiral centers. Semiempirical studies have been performed to understand the stereochemical course of the reaction. The synthesized cycloadducts have been
more » ... oadducts have been screened for antimicrobial and toxicological activity.
doi:10.1515/znb-2006-0217 fatcat:gbxwgiiwlna75f2u6spnfq2pya