Analysis of simultaneous MEG and intracranial LFP recordings during Deep Brain Stimulation: a protocol and experimental validation

Ashwini Oswal, Ashwani Jha, Spencer Neal, Alphonso Reid, David Bradbury, Peter Aston, Patricia Limousin, Tom Foltynie, Ludvic Zrinzo, Peter Brown, Vladimir Litvak
2016 Journal of Neuroscience Methods  
h i g h l i g h t s • Setup for MEG and intracranial recordings during Deep Brain Stimulation is described. • Phantom experiment showed correct recovery of oscillatory sources despite artefacts. • The method is applied to real data from a patient with Parkinson's Disease. • Cortico-subthalamic coherence profiles on and off stimulation were comparable. a b s t r a c t Background: Deep Brain Stimulation (DBS) is an effective treatment for several neurological and psychiatric disorders. In order
more » ... gain insights into the therapeutic mechanisms of DBS and to advance future therapies a better understanding of the effects of DBS on large-scale brain networks is required. New method: In this paper, we describe an experimental protocol and analysis pipeline for simultaneously performing DBS and intracranial local field potential (LFP) recordings at a target brain region during concurrent magnetoencephalography (MEG) measurement. Firstly we describe a phantom setup that allowed us to precisely characterise the MEG artefacts that occurred during DBS at clinical settings. Results: Using the phantom recordings we demonstrate that with MEG beamforming it is possible to recover oscillatory activity synchronised to a reference channel, despite the presence of high amplitude artefacts evoked by DBS. Finally, we highlight the applicability of these methods by illustrating in a single patient with Parkinson's disease (PD), that changes in cortical-subthalamic nucleus coupling can be induced by DBS. Comparison with existing approaches: To our knowledge this paper provides the first technical description of a recording and analysis pipeline for combining simultaneous cortical recordings using MEG, with intracranial LFP recordings of a target brain nucleus during DBS.
doi:10.1016/j.jneumeth.2015.11.029 pmid:26698227 pmcid:PMC4758829 fatcat:wj2t76ra2zf4zieuxqslybsmc4