Effects of Melittin on the Production of Matrix Metalloproteinase-1 and -3 in Rheumatoid Arthritic Fibroblast-Like Synoviocytes

Seong-Su Nah, Eunyoung Ha, Se Hwan Mun, Hye-Jin Won, Joo-Ho Chung
2008 Journal of Pharmacological Sciences  
Bee venom (BV) has been used in patients with rheumatoid arthritis, a condition characterized by rheumatoid joint destruction mediated, in large part, by matrix metalloproteinases (MMPs). We investigated the effects of melittin, a major component of bee venom, on the production of MMPs in human rheumatoid arthritic fibroblast-like synoviocytes (FLS). Lipopolysaccharide (LPS)-stimulated MMP3 production was significantly inhibited by melittin, which also inhibited LPS-induced DNA binding by
more » ... NA binding by nuclear factor κB (NF-κB). Mellitin had no effect on IL-1β-or TNF-α-induced MMP1 or MMP3 production and did not decrease LPSinduced secretion of MMP1. Taken together, these findings suggest that melittin may exert its anti-rheumatoid effects, at least in part, by inhibiting MMP3 production, most likely through inhibition of NF-κB activity.
doi:10.1254/jphs.sc0070215 pmid:18212480 fatcat:5nhw6bdxrnalfmsiuxaubn7q3e