GNASR201Cand KRASG12DCooperate to Induce Cystic Pancreatic Lesions

2018 Cancer Discovery  
Précis: The SHP2 inhibitor SHP099 increased the antitumor efficacy of MEK inhibition in pancreatic, lung, breast, and ovarian cancer models by preventing MEK inhibitor-induced reactivation of RAS-ERK signaling.
doi:10.1158/2159-8290.cd-rw2018-147 fatcat:fhdspz762nda3ku5otwwqzbypm