Associations between pre-pregnancy body mass index, gestational weight gain and preterm birth: a cohort study in Wuhan, China [post]

Yiyang Guo, Chao Xiong, Aifen Zhou, Ronghua Hu, Rong Yang, Yukai Du
2020 unpublished
Background Preterm birth (PTB) is the leading cause of neonatal mortality and morbidity worldwide. Methods This cohort study aims to investigate the associations between pre-pregnancy BMI, total gestational weight gain (GWG), and the GWG during early pregnancy with PTB utilizing data of 83,096 Chinese women from the Wuhan Maternal and Children Healthcare Information Tracking System in China. Results Women who were underweight, overweight or obese before pregnancy had an higher overall risk of
more » ... r overall risk of PTB compared with the normal group. Women who with a total GWG below the IOM recommendation had an increased risk of PTB compared to women who had GWG within the recommendation, whereas increased weekly early pregnancy GWG had a significant impact on the increasing risk of PTB. When stratified by subtypes of PTB, pre-pregnancy underweight was associated with higher risk of spontaneous PTB, and pre-pregnancy overweight /obese increased the risk of both spontaneous PTB and medically indicated PTB. Women with total GWG below the IOM recommendation had elevated risk for spontaneous PTB and PROM, and women with GWG above the recommendation had decreased risk for all three subtypes of PTB, whereas risk for the three subtypes of PTB increased along with increasing weekly GWG of early pregnancy. Conclusions Maternal underweight, overweight/obesity, total GWG, and GWG during early pregnancy should be considered in combination to reduce the risk of PTB, women should modify their weight gains during pregnancy according to the results.
doi:10.21203/rs.3.rs-49045/v2 fatcat:2efnc3fg5nblnaazv3hjv7y37u