The review of the russian and foreign literature on pelvic organ prolapse in women and its genetic aspects. According to the literature, an association of pelvic organ prolapse (POP) with a number of single nucleotide polymorphisms (SNPs) on chromosome 9q21, which are involved in the formation of elastic fibers of the connective tissue (CT). The association also polymorphism fibullin – 5 (FBLN5) and lysyl oxidase – like 1 (LOXL1) and theirrelationship to POP. Based on the literature, studies

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... ed at identifying the genetic nature of the POP, are incomplete and are important for the identification of risk groups who have a predisposition to POP, selecting the optimal policy for patients at risk and the initial stages of POP.