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The Geometry of Shape Space: Application to Influenza
2001
Journal of Theoretical Biology
Shape space was proposed over 20 years ago as a conceptual formalism in which to represent antibody/antigen binding. It has since played a key role in computational immunology. Antigens and antibodies are considered to be points in an abstract &&shape space", where coordinates of points in this space represent generalized physico-chemical properties associated with various (unspeci"ed) physical properties related to binding, such as geometric shape, hydrophobicity, charge, etc. Distances in
doi:10.1006/jtbi.2001.2347
pmid:11527445
fatcat:zsk77eh5yzcetie6jj3gfrpyqq