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To investigate the incidence of the contralateral neck failure (cRF) rate and outcomes among patients with well-lateralized locally advanced oral cavity squamous cell carcinoma (OSCC) with/without ipsilateral or bilateral neck adjuvant irradiation. Total 149 patients with lateralized OSCC who have undergone curative surgery with pathologically proven pT3/4 or pN0-2b between 2007–2017 were retrospectively enrolled. Those with cross midline, neck-level 1a involvement, and positive extra-nodaldoi:10.21203/rs.3.rs-1862754/v1 fatcat:iqri3tjtunfavgdgrk6xw5tedq