Noninvasive quantitation of cerebral blood flow using oxygen-15-water and a dual-PET system

H Iida, S Miura, Y Shoji, T Ogawa, H Kado, Y Narita, J Hatazawa, S Eberl, I Kanno, K Uemura
1998 Journal of Nuclear Medicine  
Measurement of the arterial input function is essential for quantitative assessment of physiological function in vivo using PET. However, frequent arterial blood sampling is invasive and labor intensive. Recently, a PET system has been developed that consists of two independent PET tomographs for simultaneously scanning the brain and heart, which should avoid the need for arterial blood sampling. The aim of this study was to validate noninvasive quantitation with this system for 15O-labeled compounds.
pmid:9776289 fatcat:gjmsfeo4ergwtbfy6bxp5azwsi