Structure and Activities of the NS1 Influenza Protein and Progress in the Development of Small-Molecule Drugs

Hyeonjin Kim, Misuk Jeong, Sebok Jang
2021 International Journal of Molecular Sciences  
The influenza virus causes human disease on a global scale and significant morbidity and mortality. The existing vaccination regime remains vulnerable to antigenic drift, and more seriously, a small number of viral mutations could lead to drug resistance. Therefore, the development of a new additional therapeutic small molecule-based anti-influenza virus is urgently required. The NS1 influenza gene plays a pivotal role in the suppression of host antiviral responses, especially by inhibiting
more » ... rferon (IFN) production and the activities of antiviral proteins, such as dsRNA-dependent serine/threonine-protein kinase R (PKR) and 2′-5′-oligoadenylate synthetase (OAS)/RNase L. NS1 also modulates important aspects of viral RNA replication, viral protein synthesis, and virus replication cycle. Taken together, small molecules that target NS1 are believed to offer a means of developing new anti-influenza drugs.
doi:10.3390/ijms22084242 pmid:33921888 fatcat:6kd57toxorgb3au454iiz24vaa