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Structure and Activities of the NS1 Influenza Protein and Progress in the Development of Small-Molecule Drugs
International Journal of Molecular Sciences
The influenza virus causes human disease on a global scale and significant morbidity and mortality. The existing vaccination regime remains vulnerable to antigenic drift, and more seriously, a small number of viral mutations could lead to drug resistance. Therefore, the development of a new additional therapeutic small molecule-based anti-influenza virus is urgently required. The NS1 influenza gene plays a pivotal role in the suppression of host antiviral responses, especially by inhibitingdoi:10.3390/ijms22084242 pmid:33921888 fatcat:6kd57toxorgb3au454iiz24vaa