We present a patient with systemic lupus erythematous (SLE) and visited emergency department, due to the progressive incoherent speech and disoriented to time in these few days. There were no obvious contact history or symptoms of infection. Due to the focal seizure, the brain magnetic resonance imaging (MRI) with gadolinium enhanced was arranged and revealed multiple ring enhancement picture and the brain abscess were suspected. The initial pathology suspected the lupus cerebritis, due to the

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... asculitis characteristic. Finally, according to the Immunohistochemistry study, the rare CNS infection of SLE patients-cerebral toxoplasmosis was confirmed the diagnosis.