The important role of research in nursing professional development increases the considerations to comparing clinical interventions, because they generate nursing evidence and knowledge. Objectives: The purpose of this study was to determine a new vision to efficacy, comparative effectiveness and cost-effectiveness research in nursing. Design: An integrative review and Delphi technique in combination. Methods: Twenty-four papers enrolled to the review over 17102 initial papers from Science

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... t, PubMed and Google Scholar databases from 2000-2021. A one round Delphi technique with 7 nursing experts was conducted to confirm or emphasize on the collected data in the review. Results: The review resulted in the characteristics of efficacy, comparative effectiveness and cost-effectiveness research. Also nursing experts mentioned the importance and existing obstacles to conduct effectiveness studies. Conclusion: The main conclusion of conducting efficacy and effectiveness research which produces complementary evidence is the reduction of the gap between theory and practice in nursing and its professional development.