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The important role of research in nursing professional development increases the considerations to comparing clinical interventions, because they generate nursing evidence and knowledge. Objectives: The purpose of this study was to determine a new vision to efficacy, comparative effectiveness and cost-effectiveness research in nursing. Design: An integrative review and Delphi technique in combination. Methods: Twenty-four papers enrolled to the review over 17102 initial papers from Sciencedoi:10.26717/bjstr.2021.40.006475 fatcat:fhp5v5jmjze5tichytprxrwbiq