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Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu
An increased number of highly active regulatory T cells (Tregs) and macrophages has been found in peritoneal fluid from women with endometriosis. Here, we show that the level of Tregs-derived soluble fibrinogen-like protein 2 (sFGL2) increases in the peritoneal fluid of women with endometriosis. Higher expression of FGL2 and its receptor CD32B is observed in eutopic endometrium and ectopic tissues. The production of sFGL2 in Tregs may be enhanced by several cytokines. sFGL2 selectively inducesdoi:10.1038/s42003-021-02018-z pmid:33893391 fatcat:hz6xuthxtvhmjkazelzvknqswa