Reconstruction of post-synaptic potentials by reverse modeling of local field potentials

Maxime Yochum, Julien Modolo, David J Mogul, Pascal Benquet, Fabrice Wendling
2019 Journal of Neural Engineering  
Among electrophysiological signals, local field potentials (LFPs) are extensively used to study brain activity, either in vivo or in vitro. LFPs are recorded with extracellular electrodes implanted in brain tissue. They reflect intermingled excitatory and inhibitory processes in neuronal assemblies. In cortical structures, LFPs mainly originate from the summation of post-synaptic potentials (PSPs), either excitatory (ePSPs) or inhibitory (iPSPs) generated at the level of pyramidal cells. The
more » ... midal cells. The challenging issue, addressed in this paper, is to estimate, from a single extracellularly-recorded signal, both ePSP and iPSP components of the LFP.
doi:10.1088/1741-2552/aafbfb pmid:30609420 fatcat:oks3paahnrdatjfu2ey4odokci