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Calcium-independent phospholipase A2mediates CREB phosphorylation in double-stranded RNA-stimulated endothelial cells
Journal of Lipid Research
One of the products of a calcium-independent phospholipase A 2 (iPLA 2 ) attack of plasmenylcholine, lysoplasmenylcholine, has previously been shown to activate cAMP-dependent protein kinase (PKA). Because endothelial cells respond to some agonists in part by the activation of iPLA 2 , the present study was designed to determine whether double-stranded RNA (dsRNA), the primary activator of the antiviral response in endothelial cells, elicits cAMP response element binding protein (CREB)doi:10.1194/jlr.m300018-jlr200 pmid:12810819 fatcat:5ojkdqwnmvcwtks44h4lenlgpu