Evaluation of type 2 diabetes genetic risk variants in Chinese adults: findings from 93,000 individuals from the China Kadoorie Biobank

Wei Gan, Robin G. Walters, Michael V. Holmes, Fiona Bragg, Iona Y. Millwood, Karina Banasik, Yiping Chen, Huaidong Du, Andri Iona, Anubha Mahajan, Ling Yang, Zheng Bian (+5 others)
2016 Diabetologia  
Aims/hypothesis Genome-wide association studies (GWAS) have discovered many risk variants for type 2 diabetes. However, estimates of the contributions of risk variants to type 2 diabetes predisposition are often based on highly selected case-control samples, and reliable estimates of populationlevel effect sizes are missing, especially in non-European populations. Methods The individual and cumulative effects of 59 established type 2 diabetes risk loci were measured in a population-based China
more » ... adoorie Biobank (CKB) study of 93,000 Chinese adults, including >7,100 diabetes cases. Results Association signals were directionally consistent between CKB and the original discovery GWAS: of 56 variants
doi:10.1007/s00125-016-3920-9 pmid:27053236 pmcid:PMC4901105 fatcat:havk74cgzzhyxnoyt5vnhgsfqu