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Sequence comparison algorithms are sophisticated pieces of software that compare and match identical or similar regions of DNA, RNA, or protein sequence. This paper examines the origins and development of these algorithms from the 1960s to the 1990s. By treating this software as a kind of scientiªc instrument used to examine sets of biological objects, the paper shows how algorithms have been used as different sorts of tools and appropriated for different sorts of uses according to thedoi:10.1162/posc_a_00042 fatcat:wogni66rd5a5pdwke6fxtjixri