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Critical evaluation of the newborn screening for congenital hypothyroidism in the Netherlands
European Journal of Endocrinology
Objective: Congenital hypothyroidism (CH) is defined as thyroid hormone deficiency at birth due to disorders of the thyroid gland (thyroidal CH, CH-T), or the hypothalamus or pituitary (central CH, CH-C). The Dutch Newborn Screening (NBS) strategy is primarily based on determination of thyroxine (T4) concentrations in dried blood spots followed, if necessary, by thyroid-stimulating hormone (TSH) and thyroxine-binding globulin (TBG) measurement enabling detection of both CH-T and CH-C. Adoi:10.1530/eje-19-1048 pmid:32580148 fatcat:zpcre2e7lnhkpdymgn7g5xue6a