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Investigations were made with the new burley variety B 2/93, bred in the Tobacco Institute Prilep, on alluvial soil type in the producing region of Ohrid and Struga. Four rates of nitrogen fertilizer (55, 100, 150, and 200 kg ha-1) and a constant rate of phosphorus and potassium were applied in the investigation. Based on the results obtained, it can be stated that fertilization and irrigation have a significant influence on the anatomic structure of burley tobacco leaf. The best developeddoi:10.2478/cttr-2013-0800 fatcat:huouyntsg5dkjgewrgo2thwrxm