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Growth factor messenger RNA expression by human breast fibroblasts from benign and malignant lesions
Breast tumors are a complex mix of epithelial, stromal, and vascular elements. We examined primary cultures of breast fibroblasts derived from benign and malignant lesions for expression of various growth factors. All fibroblast cultures, regardless of whether they were derived from benign or malignant lesions, expressed platelet-derived growth factor A chain, basic fibroblast growth factor, fibroblast growth factor 5, and transforming growth factor beta 1 mRNA. None expressed platelet-derivedpmid:1893385 fatcat:46ozu5zq6rfndkxww6oydqgcju