Aluminum Ingestion Promotes Colorectal Hypersensitivity in Rodents

Nicolas Esquerre, Lilian Basso, Caroline Dubuquoy, Madjid Djouina, Daniel Chappard, Catherine Blanpied, Pierre Desreumaux, Nathalie Vergnolle, Cécile Vignal, Mathilde Body-Malapel
2019 Cellular and Molecular Gastroenterology and Hepatology  
Irritable bowel syndrome (IBS) is a multifactorial disease arising from a complex interplay between genetic predisposition and environmental influences. To date, environmental triggers are not well known. Aluminum is commonly present in food, notably by its use as food additive. We investigated the effects of aluminum ingestion in rodent models of visceral hypersensitivity, and the mechanisms involved.
doi:10.1016/j.jcmgh.2018.09.012 pmid:30534582 pmcid:PMC6280602 fatcat:hd4p4snrwnc53e7q4kirqazg7a