Objective Pain and in ammatory conditions are the commonest health problems reported to this date. The advent of numerous pharmacologic agents cannot still abated the demand due to the associated side effects, the search for satisfactory new molecule particularly from herbal sources is the main endeavor as experience shows. Thus, this study evaluated the analgesic activity of the 80% methanol leaf extract of Otostegia integrifolia in mice models of pain. Results Analgesic effect of various oral

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... doses of the hydro-alcoholic extract (100, 200 and 400 mg/kg) was determined in hot plate and acetic acid induced writhing methods. In all models, the higher doses of the extract (400mg/kg) exhibited signi cant central and peripheral analgesic activities without signi cant difference compared to the standard drugs morphine and aspirin respectively. However, the lowest dose of the extract lacks central analgesic activity. The experimental nding from this study corroborates perhaps the presence of similar constituents within the genus Otostegia that might be responsible for the analgesic effects observed on other species. Thus, Otostegia integrifolia could be potential source for development of new analgesics.