Tunable Degradation Rate and Favorable Bioactivity of Porous Calcium Sulfate Scaffolds by Introducing Nano-Hydroxyapatite

Jianhua Zhou, Fulai Yuan, Shuping Peng, Hui Xie, Ping Wu, Pei Feng, Chengde Gao, Youwen Yang, Wang Guo, Duan Lai, Zhiyang Zhou, Xueling Zhu (+1 others)
2016 Applied Sciences  
The bone scaffolds should possess suitable physicochemical properties and osteogenic activities. In this study, porous calcium sulfate (CaSO 4 ) scaffolds were fabricated successfully via selected laser sintering (SLS). Nano-hydroxyapatite (nHAp), a bioactive material with a low degradation rate, was introduced into CaSO 4 scaffolds to overcome the overquick absorption. The results demonstrated that nHAp could not only control the degradation rate of scaffolds by adjusting their content, but
more » ... eir content, but also improve the pH environment by alleviating the acidification progress during the degradation of CaSO 4 scaffolds. Moreover, the improved scaffolds were covered completely with the apatite spherulites in simulated body fluid (SBF), showing their favorable bioactivity. In addition, the compression strength and fracture toughness were distinctly enhanced, which could be ascribed to large specific area of nHAp and the corresponding stress transfer.
doi:10.3390/app6120411 fatcat:7fp4nw72b5f5zoorsg4jeuoeym