Indicative to the use of leukocyte dialysate extract in clinical practice

Дмитрий Мальцев
2020 Immunology and Allergy: Science and Practice  
Experience in the use of factor transfer in medicine is more than 60 years, and begins with the proposal of F. Lawrence in 1955 to use dialysed leukocyte blood extract to transfer antitumor immunity from the immunized body to non-immune.Preparations of immune extract of leukocyte dialysate are an important component of modern science about transfer factors. It is a highly active multicomponent immunobiological agent of natural origin, containing more than 200 low molecular weight peptides,
more » ... ight peptides, which are components of the immune system of the human body, mainly – products of synthetic activity of CD8+ cytotoxic T-lymphocytes.This biological preparation has immunosubstitutional, immunizing and immunomodulatory biological properties, which are implemented inseparably from each other, providing known anti-infectious, pro-/antiinflammatory, tolerogenic, immunoactivating and antitumor therapeutic effects.The drug based on the immune extract of leukocytes dialysate is included in the modern international protocols for the treatment of primary immunodeficiency – hereditary skin and mucous candidiasis. In addition, at the moment there are at least 30 more indications with varying degrees of evidence for the clinical use of such transfer factors in immunology, infectology, allergology, rheumatology and oncology.The main immunomodulatory effect of the drug is associated with increased functioning of T-helpers type 1 by stimulating the production of cytokines interleukin-2 and gamma-interferon, which leads to the potentiation of cellular immune response. This immunomodulatory effect can be explained by the efficacy of transfer factor in some cellular and combined primary and secondary immunodeficiencies, chronic infections caused by intracellular microorganisms, and various malignancies. The reciprocal decrease in functional activity of T-helpers type 2 leads to attenuation of atopic allergic reactions and some types of autoimmunity, which explains moderate success of transfer factor in allergology and rheumatology.
doi:10.37321/immunology.2020.02-04 fatcat:7hghz57hmjbsnif54g6p6opunm