Topical Mitomycin Application After Laryngotracheal Reconstruction

Christopher J. Hartnick, Benjamin E. J. Hartley, Peter D. Lacy, James Liu, Judy A. Bean, J. Paul Willging, Charles M. Myer III, Robin T. Cotton
2001 Archives of Otolaryngology - Head and Neck Surgery  
Objective: To explore the effect of mitomycin treatment on the pediatric airway following laryngotracheal reconstruction. Design: Randomized, double-blind, placebo-controlled trial. Patients: Children aged 2 to 17 years with subglottic or upper tracheal stenosis undergoing laryngotracheal reconstruction at a single, tertiary care, children's hospital. Intervention: At the time of extubation or stent removal, the children underwent bronchoscopy and 0.4 mg/mL (2 mL of a 0.2-mg/mL solution of
more » ... r mitomycin or an equal volume of isotonic sodium chloride was directly applied to the subglottic region for a single application of 2 minutes. These children then underwent interval endoscopy at 2 weeks, 6 weeks, and 3 months postoperatively for assessment of their airways.
doi:10.1001/archotol.127.10.1260 pmid:11587609 fatcat:26w27dml4resllsqxm7wqogkni