This study was conducted to evaluate the influence of smoking habit on the success of periodontal regeneration in treating intra-bony periodontal defects when using Platelet Rich Plasma (PRP) combined with Freeze Dried Bone Allograft (FDBA). Thirty patients all diagnosed as having advanced chronic periodontitis were selected. The patients were equally allocated into two equal groups: Group I; (n=15) which included non-smoking patients having periodontal intra-bony defects managed with PRP and

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... aged with PRP and FDBA and Group II; (n=15) included smoking patients having periodontal intra-bony defects managed with PRP and FDBA. Clinical evaluation recording the plaque index (PI), gingival index (GI), pocket depth (PD), and clinical attachment level (CAL) was done. Radiographic assessment was also carried out to calculate the amount of bone gain. Estimation of the level of Platelet Derived Growth Factor (PDGF-BB) was performed. The results revealed that the clinical improvement, the amount of bone gain and the level of PDGF-BB were more in the non-smokers group. Smoking has a negative impact on the treatment outcomes of the periodontal intra-bony defects following the combined treatment of PRP and FDBA.