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Ubiquitination-Mediated Inflammasome Activation during Bacterial Infection
International Journal of Molecular Sciences
Inflammasome activation is essential for host immune responses during pathogenic infection and sterile signals insult, whereas excessive activation is injurious. Thus, inflammasome activation is tightly regulated at multiple layers. Ubiquitination is an important post-translational modification for orchestrating inflammatory immune responses during pathogenic infection, and a major target hijacked by pathogenic bacteria for promoting their survival and proliferation. This review summarizesdoi:10.3390/ijms20092110 fatcat:nh4uwl6ixbd2vetrdjfavbza3a