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Novel Organization and Properties of Annexin 2-Membrane Complexes
2003
Journal of Biological Chemistry
Annexin 2 belongs to the annexin family of proteins that bind to phospholipid membranes in a Ca 2؉ -dependent manner. Here we show that, under mild acidic conditions, annexin 2 binds to and aggregates membranes containing anionic phospholipids, a fact that questions the mechanism of its interaction with membranes via Ca 2؉ bridges only. The H ؉ sensitivity of annexin 2-mediated aggregation is modulated by lipid composition (i.e. cholesterol content). Cryo-electron microscopy of aggregated
doi:10.1074/jbc.m313657200
pmid:14701819
fatcat:dxy2tn4axjh7ve3mfwz22ohtqq