Allergic diseases and asthma are an important problem in health system and effects large amounts of people in the worlds. Exposure to outdoor and indoor allergens promote the sensitization towards these allergens. Th2 cytokines are main stimulators allergic diseases initiation. Allergic diseases similar to other diseases have been studied in animal for understanding of pathophysiology and treatments. Animal models provide a potential approach to investigation of the pathophysiology, mechanism

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... d drugs designing for allergy and asthma. Physicians and veterinarians with collaboration in this field could improve best animal model. In this review, it will be discussed the various models (especially in mouse) and protocols by focusing on the allergic diseases. Animal models in allergy field, are applicable for important goals. Moral discussion in all procedures should be remarkable.