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Synthesis of (5R,8R)-2-(3,8-Dimethyl-2-oxo-1,2,4,5,6,7,8,8α-octahydroazulen-5-yl) Acrylic Acid (Rupestonic Acid) Amide Derivatives and in vitro Inhibitive Activities against Influenza A3,B and Herpes Simplex Type 1 and 2 Virus
Bulletin of the Korean Chemical Society (Print)
19 Aromatic ring and L-amino acid ester contained rupestonic acid amide derivatives 2a~2l, 3a~3g were synthesized and preliminarily evaluated in vitro against influenza virus A3,B and herpes simplex virus type 1 (HSV-1), 2(HSV-2) by the national center for drug screening of China. The rusults showed that 2i possessed the highest inhibition against both influenza virus A3 (TC50 = 120.6 µmol/L, IC50 = 19.2 µmol/L, SI = 6.3) and B (TC50 = 120.6 µmol/L, IC50 = 29.9 µmol/L, SI = 4.0); 2g was moredoi:10.5012/bkcs.2009.30.2.435 fatcat:ltyg633epfarlpkkhvkjvlr5mm