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2011 10th International Workshop on Biomedical Engineering
A simplified network describing the interactions between the cholesterol and beta amyloid (Aβ) synthesis pathways was generated using information available from literature and the KEGG database. A system of non-linear differential equations was developed and modeled using several different initial conditions. Rate constants were approximated using ratio-metric data from the literature, or by fitting parameters to obtain a stable simulation within given biological constraints. Simulationsdoi:10.1109/iwbe.2011.6079047 fatcat:lnao3glnbfayjlzfwedenskz7i