Objective: To determine the benefit of nasally inhaled dornase alfa in cystic fibrosis (CF) sinusitis. Design: Retrospective chart review comparing postsurgical course, radiographic studies, and pulmonary function test results in patients who were treated with nasally inhaled dornase alfa with those in patients who were not treated with dornase alfa. Patients: Twenty consecutive patients with CF who underwent functional endoscopic sinus surgery from 1993 to 1997 were included in the study.

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... ment with nasally inhaled dornase alfa was initiated in 5 of the 20 patients after they underwent functional endoscopic sinus surgery. Setting: Tertiary care academic center. Results: The dornase alfa-treated patients had less mu-