Mycophenolate Mofetil (MMF or CellCept) has been known as a potent agent for immunosuppression especially used in the treatment of ongoing rejection in organ transplant. It is now used for recalcitrant conditions of dire autoimmune disorders especially in the setting of lack of response to first line agents. MMF causes an array of gastrointestinal side effects such as nausea and vomiting, afebrile diarrhea, diffuse colitis. Others include insomnia, anxiety, easy bleeding and mental/mood

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... nces. Although fast and irregular heart beat was identified as a serious but very rare side effect of MMF, its incidence remains very low and rarely reported. We present a case of new onset supraventricular tachycardia two months after starting MMF for severe scleroderma in the setting of non-response to methotrexate therapy.