Occurrence of Plasmid-mediated AmpC β-lactamases among Enterobacter cloacae, Serratia marcescens and Citrobacter freundii in China

J Cheng, X-J Ma, J Sun, Y Ye
2016 West Indian medical journal  
A total of 775 consecutive non-duplicate isolates of Enterobacteriaceae (534 E. cloacae, 137 S. marcescens and 104 C. freundii) were collected from 2005 to 2014 at 34 hospitals in Anhui Province, China. Material and Methods: The detection of plasmid-mediated AmpC β-lactamases (pAmpCs) was based on the inhibitor screening method. Then, the association with other β-lactamases and mobile genetic elements, like class 1 integron, ISCR1 and ISEcp1, were analyzed by molecular biology method. Results:
more » ... y method. Results: Among the total of 775 isolates, the prevalence of pAmpC was discovered to be 8.1% (63/775) overall. In this study, the presence of pAmpCs was significantly linked to other β-lactamases and mobile genetic elements, among which bla CTX-M and class 1 integron were the most prevalent genotype. Conclusion: Therefore, various combinations of β-lactamases and mobile genetic elements were detected in the study. Plasmids were demonstrated to be the main vehicles for the dissemination of pAmpC genes.
doi:10.7727/wimj.2016.190 fatcat:nb7nspcy5nc67hwcsq4cmligyu