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Background-Many cases of idiopathic dilated cardiomyopathy (IDC) result from an inflammatory myocarditis. The specific immunological mechanisms are not yet defined. Various autoimmune diseases are associated with superantigentriggered immune responses, resulting in massive T-cell activation and tissue damage. We studied 3 cases in a search for evidence that such a phenomenon is also implicated in IDC. Methods and Results-Myocardial, lymph node, and thymic tissue samples were obtained from IDCdoi:10.1161/01.cir.98.8.777 pmid:9727548 fatcat:kypjmqqlxfh7xlwa5k5bgbdd4m