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The role of the bone marrow microenvironment in multiple myeloma
Histology and Histopathology
Multiple myeloma (MM) is a malignant disease that results from an excess of monotypic plasma cells in the bone marrow (BM). This malignancy is characterised by complex karyotypic aberrancies. In 60% of all MM there are recurrent primary translocations involving the heavy chain gene locus. The MM cells strongly interact with the BM microenvironment, which is composed of endothelial cells, stromal cells, osteoclasts, osteoblasts, immune cells, fat cells and the extracellular matrix. Thisdoi:10.14670/hh-20.1227 pmid:16136504 fatcat:kq7mpemfeff3bpc5c4y2ifelay