Differential growth factor regulation of N-cadherin expression and motility in normal and malignant oral epithelium

M. E. Diamond, L. Sun, A. J. Ottaviano, M. J. Joseph, H. G. Munshi
2008 Journal of Cell Science  
promoter activity exclusively in oral keratinocytes but not in OSCC cells. The effect of EGF on TGFβ1-mediated Smad-driven promoter activity and N-cadherin expression was reversed when activation of ERK1/2 was blocked. Although EGF and TGFβ1 independently promoted migration of both oral keratinocytes and OSCC cells, EGF decreased TGFβ1-mediated migration of oral keratinocytes but enhanced migration of OSCC cells. Together, these data support a model wherein EGF signaling has an important
more » ... e regulatory role on TGFβ1-mediated N-cadherin expression and motility in normal oral keratinocytes, and in which loss of this regulatory mechanism accompanies malignant transformation of the oral epithelium.
doi:10.1242/jcs.021782 pmid:18544635 fatcat:vdnshdmeqfbxdfhxpu7tak4rbq