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Melanoma is a neoplasm whose biology we are getting to know better and better. The consequence of this is the latest edition of "WHO Classification of Skin Tumours 4 th edition, 2018". The division presented in this paper takes into account the character of growth and location of melanoma, but also results from the analysis of the most frequent mutations occurring in this neoplasm. The assessment of the stage of melanoma progression, based on two most important prognostic microscopic features,doi:10.5603/njo.2019.0020 fatcat:oujmwlxkifebjjdbr3o2xzahoy