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Use of exhaled breath condensate (EBC) in the diagnosis of SARS-COV-2 (COVID-19)
2020
Thorax
Preserved Fulltext
False negatives from nasopharyngeal swabs (NPS) using reverse transcriptase PCR (RT-PCR) in SARS-CoV-2 are high. Exhaled breath condensate (EBC) contains lower respiratory droplets that may improve detection. We performed EBC RT-PCR for SARS-CoV-2 genes (E, S, N, ORF1ab) on NPS-positive (n=16) and NPS-negative/clinically positive COVID-19 patients (n=15) using two commercial assays. EBC detected SARS-CoV-2 in 93.5% (29/31) using the four genes. Pre-SARS-CoV-2 era controls (n=14) were negative.
doi:10.1136/thoraxjnl-2020-215705
pmid:33097604
fatcat:ydnelvfzmjgxdp2ykvznpoukji