Fulvestrant-induced toxic epidermal necrolysis

Macarena Morales-Conde, Natividad López-Ibáñez, Julio Calvete-Candenas, Francisco Manuel Ildefonso Mendonça
2019 Anais Brasileiros de Dermatologia  
Toxic epidermal necrolysis is a condition with massive keratinocyte apoptosis, and it is associated with high mortality rates. Fulvestrant, an estrogen receptor antagonist, is indicated in the treatment of estrogen receptor-positive metastatic breast cancer in postmenopausal women. To our knowledge, this is the first described case of toxic epidermal necrolysis due to fulvestrant. A 56-year-old woman received 500 mg of intramuscular fulvestrant monthly for metastatic ductal carcinoma of the
more » ... arcinoma of the breast. Five days after the first dose, the patient presented with a maculopapular rash that evolved to blisters, and a detachment of the epidermis in over 30% of the total body surface area. Histological analysis was compatible with toxic epidermal necrolysis. Fulvestrant was discontinued, topical management and supportive care were initiated.
doi:10.1590/abd1806-4841.20197964 pmid:33261799 fatcat:ja2vcguo7ves3pofgfbkab4nqy