EXPERIENCE OF INTRAMUSCULAR METHOTREXATE USE IN A PATIENT WITH EARLY POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS

E. I. Alexeeva, T. V. Sleptsova, T. M. Bzarova, S. I. Valieva, R. V. Denisova, K. B. Isaeva, E. V. Mitenko, E. G. Chistyakova, A. M. Chomakhidze, A. N. Fetisova, O. L. Lomakina, N. I. Taybulatov
2014 Pediatričeskaâ Farmakologiâ  
Experience of intramuscular methotrexate use in a patient with early polyarticular juvenile idiopathic arthritis Author affiliation: Alexeeva Ekaterina Iosifovna, PhD, Professor, head of the SCCH rheumatology department, dean of the Faculty of Pediatrics at Sechenov First MSMU Address: 2/62 Lomonosovskii Av., Moscow, 119991, tel.: +7 (499) 134-14-94 Article This article presents a case of severe course of polyarticular juvenile idiopathic arthritis. Active articular syndrome, high laboratory
more » ... high laboratory parameters of disease activity, severe incompetence were observed in a child by the therapy initiation. Successful use of intramuscular methotrexate in the dose of 15 mg/m 2 of body surface per week is described. Exudative articular alterations, arthralgiae, morning stiffness duration reduced as early as one month after the therapy initiation in a child. Acute inflammatory articular alterations cut off, range of motions recovered completely in 4 out of the 6 affected joints, laboratory parameters of disease activity reduced and normalized (ESR and CRP), inactive disease stage was registered after 6 months of treatment. We did not observe any undesirable phenomena in the setting of methotrexate therapy.
doi:10.15690/pf.v11i2.957 fatcat:2josjv25qbactkvktfp4csolja